Weight loss has become a major health focus for many Canadians, with millions seeking safe and effective solutions to shed excess pounds. Among the newest and most popular options are injectable medications like Mounjaro and Ozempic. Both belong to a class of drugs initially designed for diabetes management but are now celebrated for their impressive weight loss benefits.
If you’re wondering which medication might be right for you, this comprehensive guide will walk you through the key mounjaro vs ozempic differences, benefits, costs, and safety considerations to help you make an informed decision. We’ll also look at how DooÜ can help you get prescribed safely and conveniently.
1. What are Mounjaro and Ozempic?
Mounjaro is the brand name for tirzepatide, a newer medication approved in Canada primarily for managing type 2 diabetes. It’s unique because it acts as a dual agonist, stimulating both the GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors. This dual action helps regulate blood sugar more effectively and reduces appetite, leading to weight loss.
Ozempic, a semaglutide-based medication developed by Novo Nordisk, has been available in Canada for a longer period. Like Mounjaro, it targets the GLP-1 receptor but only acts on that single receptor. Ozempic is also approved for type 2 diabetes but has gained popularity for its off-label use in weight loss and is the basis for the higher-dose weight loss drug Wegovy.
Both medications are prescription-only, and their use for weight loss is becoming more common as evidence of their effectiveness grows.
2. How Do Mounjaro and Ozempic Work for Weight Loss?
Mounjaro’s dual mechanism targets two hormones, GIP and GLP-1, that regulate appetite and insulin response. By activating these receptors, it enhances insulin sensitivity, reduces hunger, and slows gastric emptying through GLP-1, helping you feel full longer.
Ozempic works by mimicking GLP-1, a natural hormone that increases insulin release after meals and suppresses appetite.
Simply put, both medications tell your brain you’re full and help your body use insulin more efficiently, which contributes to steady, sustained weight loss.
3. Mounjaro vs Ozempic Weight Loss Results Compared
Clinical trials like the SURMOUNT Trials and the STEP Trials provide strong evidence demonstrating the effectiveness of both medications for weight loss. The table below summarizes key data from major clinical studies and practical considerations regarding results and maintenance.
4. Dosage and Administration: How Mounjaro and Ozempic are Taken Under DooÜ Prescription
Both Mounjaro and Ozempic are administered as once-weekly injections under the skin, usually in areas like the abdomen, thigh, or upper arm. However, mounjaro vs ozempic dosage formats and storage stability differ. The mounjaro vs ozempic dosage chart below provides an overview of how each medication is taken and the different dosage details.
5. Cost comparison in Canada
Cost is an important factor when choosing between Mounjaro and Ozempic. Mounjaro is generally more expensive than Ozempic in Canada due to its newer market entry, dual-action formulation, and higher dosing requirements. Here’s a quick comparison of their typical costs in Canada:
How to save money
- Use patient assistance programs and coupons available through the manufacturers of Mounjaro and Ozempic to reduce out-of-pocket costs.
- At DooÜ, we offer the lowest program fee in Canada at just $90! This includes an initial assessment with a Canadian doctor, clinically proven treatment, and discreet delivery right to your door. DooÜ makes weight loss treatment more affordable and easy to access for you.
6. Side effects and safety profile
Mounjaro and Ozempic have similar side effect profiles and safety considerations since both belong to the class of GLP-1 receptor agonists (with Mounjaro also activating GIP receptors). However, Mounjaro may be associated with a higher frequency and severity of certain side effects, especially gastrointestinal issues. Understanding the most common side effects of Mounjaro and the side effects of Ozempic, as well as potential risks, can help you prepare for treatment and recognize any issues early.
Common side effects
Many people experience mild to moderate Mounjaro side effects or Ozempic side effects when starting these medications. These usually improve after the first few weeks as your body adjusts. The most frequently reported symptoms include:
- Nausea
- Vomiting
- Diarrhoea
- Constipation
- Decreased appetite
- Injection site reactions such as redness, itching, or swelling
These symptoms are typically temporary and manageable with proper guidance from your healthcare provider.
Notably, gastrointestinal side effects tend to be more frequent and severe with Mounjaro, particularly at higher doses. Clinical trials of tirzepatide (Mounjaro) report treatment discontinuation due to GI adverse events ranging from ~4% (at lower doses) to ~10.5% (at maximum tolerated doses. This makes early monitoring and gradual dose escalation especially important.
Serious warnings and precautions
While adverse events are uncommon, it’s important to be aware of serious side effects and potential complications associated with both drugs:
- Severe gastrointestinal disease: Mounjaro’s prescribing information includes specific warnings about serious GI issues such as gastroparesis or intestinal blockage. Although rare, these effects can be more pronounced with this medication and may require stopping treatment.
- Pancreatitis: There is a possible risk of inflammation of the pancreas. Seek immediate medical help if you experience severe abdominal pain.
- Thyroid cancer risk: Neither medication is recommended for people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 due to an increased risk of thyroid tumors.
- Kidney problems: Caution is advised if you have kidney issues or chronic kidney disease, as fluid loss from vomiting or diarrhea can worsen kidney function.
- Allergic reactions: Although rare, some individuals may experience allergic responses, including rash, swelling, or difficulty breathing. Seek medical attention if these occur.
- Heart complications: Patients with existing heart disease or a history of heart attack should inform their healthcare provider, as there may be risks that require close monitoring.
Before starting treatment, make sure to discuss your full medical history with your healthcare professional. This helps ensure the safest possible use of these medications and helps tailor the treatment to your individual health profile.
7. Alternatives to Consider
While Mounjaro and Ozempic are among the most talked-about weight loss medications, several other options and new drugs are approved or emerging in Canada that you might want to consider depending on your specific needs, health conditions, and preferences.
Wegovy (High-Dose Semaglutide)
Wegovy is essentially a higher dose version of semaglutide, the active ingredient in Ozempic, specifically approved for chronic weight management. It works by activating the GLP-1 receptor to help regulate appetite and improve blood sugar levels. It is often preferred when a higher dose of semaglutide is needed compared to Ozempic, making it a more targeted option for Canadians seeking significant weight loss.
Saxenda (Liraglutide)
Saxenda contains liraglutide, another GLP-1 receptor agonist used for weight loss. It is similar in action to Ozempic but requires daily injections instead of weekly. Saxenda has been approved in Canada for weight management in adults and works by helping you feel full sooner and reducing hunger cravings.
Zepbound (Emerging GLP-1 Medication)
Zepbound is a promising new GLP-1 receptor agonist currently under review and pending approval in Canada. It aims to offer a similar appetite-suppressing and blood sugar-regulating effect as existing GLP-1 drugs but may provide additional benefits such as fewer side effects or improved dosing convenience and drug administration.
8. Ozempic vs Mounjaro for Weight Loss: Which Medication is Right for You?
Choosing between Mounjaro and Ozempic depends on your individual health needs, weight loss goals, medical history, and practical considerations such as insurance coverage. Here’s a detailed look at who might benefit most from each weight loss medication:
Consider Mounjaro if you:
1. Want potentially greater weight loss results:
Mounjaro’s dual action on both GIP and GLP-1 receptors often leads to more significant weight loss compared to GLP-1 only medications. If your primary goal is maximum weight reduction, Mounjaro may offer an advantage.
2. Prefer dual-action therapy:
Because it targets two hormones involved in appetite regulation and insulin sensitivity, Mounjaro may provide enhanced metabolic benefits. This makes it suitable for those seeking comprehensive treatment effects.
3. Have type 2 diabetes needing advanced management:
For patients with type 2 diabetes who want to control or lower blood sugar levels along with weight loss, Mounjaro’s dual receptor mechanism offers a valuable option. It can provide improved glycemic management alongside weight benefits.
4. Are willing to tolerate gradual dose escalation:
Mounjaro typically requires a slower dose increase to minimize side effects. If you are comfortable with this process and committed to ongoing monitoring, it may be a good fit.
Consider Ozempic if you:
1. Are looking for a well-established medication with a long safety record:
Ozempic has been on the market longer and has accumulated extensive clinical experience and post-market safety data. If you value a medication with a proven track record, Ozempic may be preferable.
2. Prefer a single-action GLP-1 option:
Some patients respond better or tolerate single receptor agonists more easily. Ozempic’s targeted GLP-1 action may reduce certain side effects or complications for some individuals.
3. Have insurance that covers Ozempic specifically:
Insurance plans and provincial drug benefits vary widely. If your coverage includes Ozempic but not Mounjaro, choosing Ozempic may reduce out-of-pocket expenses and improve accessibility.
4. Want a simpler dosing schedule:
Ozempic typically starts at a low dose and escalates more quickly than Mounjaro, which may be preferable for those who want to reach an effective dose faster.
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10. Final Thoughts
Both Mounjaro and Ozempic are effective options for weight loss and type 2 diabetes management. Mounjaro’s dual-action may offer greater weight loss and metabolic benefits, while Ozempic’s longer use and simpler dosing make it a trusted choice. The right medication depends on your health goals, medical history, side effect tolerance, and insurance coverage. Consulting a healthcare professional through DOOU can help you get safe, personalized guidance for a confident and effective weight loss journey.
Frequently Asked Questions
Are Mounjaro and Ozempic covered by insurance in Canada for weight loss?
Coverage varies by province and insurance plan. For example, some group health plans may cover Ozempic for weight loss if medically required, but this often requires pre-authorization. Mounjaro is generally not covered for weight loss under most insurance plans.
Can I switch from Ozempic to Mounjaro, and how should the dosage be adjusted?
Switching from Ozempic to Mounjaro should be done under medical supervision. A healthcare provider may recommend starting with a lower dose of Mounjaro to assess tolerance. For instance, if you're on Ozempic 0.5 mg weekly, your provider may suggest starting with Mounjaro 2.5 mg weekly.
Can Mounjaro or Ozempic be used without having type 2 diabetes?
Yes, both Mounjaro and Ozempic can be prescribed off-label for weight loss in individuals without type 2 diabetes. However, this should always be done under close medical supervision to ensure safety and to monitor for any potential side effects.
How quickly can I expect to see weight loss results with Mounjaro or Ozempic?
Most users start to see noticeable weight loss within 4 to 8 weeks of beginning Mounjaro or Ozempic treatment. Results can vary based on factors like dosage, diet, exercise, and individual metabolism, so timelines may differ from person to person.
Are there lifestyle changes I need to follow while taking Mounjaro or Ozempic?
While Mounjaro and Ozempic help promote weight loss, it’s important to complement treatment with a balanced diet, food intake, and regular physical activity. These lifestyle changes enhance the medications’ effectiveness and are key to maintaining weight loss over the long term.