When it comes to effectively managing type 2 diabetes and weight loss medications, the selection of the appropriate medication plays a crucial role. Among the various options available, two widely recognized choices are Mounjaro and Contrave. Each of these prescription weight loss medications possesses distinct advantages for helping individuals lose weight, making it essential to delve into their mechanisms of action, efficacy, method of administration, potential side effects, and cost to make a well-informed decision.
Mounjaro and Contrave are available in Canada and are approved by Health Canada for diabetes and weight loss.
What is Contrave?
Contrave is a prescription weight loss medication that is a combination of two active ingredients: naltrexone and bupropion. Naltrexone is an opioid antagonist that works by reducing the desire for food, while bupropion is an antidepressant that also acts to suppress appetite and increase metabolic rate. When used together, these drugs can assist individuals to lose weight by lowering their calorie intake and raising their energy expenditure.
Contrave is often prescribed as part of a comprehensive weight loss plan, particularly for individuals whose body mass index classifies them as overweight or obese. As with many anti-obesity medications, it is most effective when paired with lifestyle changes such as a healthy diet and regular exercise.
Which is More Effective for Weight Loss - Mounjaro or Contrave?
Both medications, Mounjaro and Contrave, have shown significant potential in helping patients lose weight and manage long-term weight loss, especially for individuals with a higher body mass index. However, the most effective results are observed when these anti-obesity medications are used in conjunction with a balanced diet and regular exercise.
In a research study for Mounjaro, an extensive clinical trial involved over 2500 participants and assessed the effectiveness of Mounjaro in managing weight loss. Non-diabetic participants struggling with overweight were administered various doses of Mounjaro for 72 weeks, alongside a calorie-restricted diet (500 kcal/day), 150 minutes of weekly exercise, and regular consultations with a dietitian and nutritionist.
The trial revealed that after 72 weeks, each group receiving Mounjaro exhibited substantial weight loss compared to the placebo group. Every treatment group experienced a 15-20% change in weight from the beginning of the trial, with higher doses of Mounjaro demonstrating more pronounced effects. These findings underscore the effectiveness of Mounjaro when combined with diet and exercise in treating weight loss.
Contrave's efficacy in weight loss was highlighted in a well-known trial published in 2010. This trial investigated the weight loss effects of Contrave in overweight patients. Participants were administered oral Contrave for 52 weeks, alongside a calorie-restricted diet and regular exercise. The results revealed that after 52 weeks, nearly half of the participants taking Contrave experienced a minimum of 5% reduction in weight. Subsequent clinical trials further reinforced the benefits of Contrave for weight loss.
Comparing Mounjaro vs. Contrave Prices in Canada
Price for weight loss medications can be a significant factor in choosing between Mounjaro and Contrave. Here’s a general guide to their costs:
- Dosage: Higher dosages can lead to higher costs.
- Pharmacy: Prices may vary between pharmacies, prices also vary between online pharmacies and retail pharmacies.
- Online weight loss clinics: Some new healthcare companies, like Felixforyou, Livewell, Science and Humen, and DooU, offer Mounjaro prices ranging from $400/ box to $540/box.
- Insurance Coverage: Your insurance may not cover the cost of this medication for the weight loss program.
For the most accurate and up-to-date pricing:
- Contact Your Insurance Provider: Check what is covered for both medications.
- Compare Pharmacy Prices: Visit different pharmacies to find the best rate.
- Explore Generic Options: If available, generics might offer cost savings.
Can You Take Mounjaro and Contrave Together for Weight Loss?
It is not recommended to take Mounjaro and Contrave together. Using both medications simultaneously could increase the risk of side effects due to their different mechanisms of action. Always consult your healthcare provider before combining or switching medications.
What Is The Average Weight Loss on Mounjaro vs. Contrave?
Individual weight loss results will vary between individuals, and will depend on the patient's individuals health goals and needs. Contrave and Mounjaro have both been shown to be effective medications for long-term weight reduction which can result in improvements in other weight-related health conditions.
When comparing studies on each medication, there is a higher percentage of patients achieving better weight loss with Mounjaro. Though Mounjaro appears to be more effective, Contrave may be more convenient for patients who do not wish to use injectable medications.
Switching from Mounjaro to Contrave or Contrave to Mounjaro for Weight Loss?
Switching between Mounjaro and Contrave is generally not advised unless guided by your healthcare provider. Both medications offer weight loss benefits but through different approaches.
Switching may not provide additional benefits and could heighten the risk of side effects. If considering a switch, discuss your options with your healthcare provider to assess whether it aligns with your health needs and weight loss goals.